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. Author manuscript; available in PMC: 2013 Jan 31.
Published in final edited form as: Clin Pharmacol Ther. 2011 May 11;90(1):100–108. doi: 10.1038/clpt.2011.59

Figure 4.

Figure 4

Relationship between rifampin dose and CYP3A induction, assessed by the plasma concentration AUC ratio, for both MDZ and ALF. Results are shown as the arithmetic mean ± SD (n=12). Dose-response curves were determined using the Hill equation, and non-linear regression analysis of individual data. Lines represent predicted values based on regression parameters. Significant differences between MDZ and ALF ratios at the same rifampin dose, assessed by 2-way repeated measures analysis of variance, are indicated by asterisks (p<0.05) Results for induction by 600 mg rifampin are from a previous publication, and were also assessed by 2-way repeated measures analysis of variance.10