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Oxaliplatin elucidated action mechanism centers around the formation of Pt-GG adducts in DNA. (A). This Pt-DNA NMR structure visualizes the 15 lowest energy solution structures of Oxaliplatin-GG 12-mer DNA adduct (B). Figures were adapted from Protein Interactions with Platinum-DNA Adducts: From Structure to Function, Chaney et al. 2004 from the Journal of Inorganic Biochemistry (OpenAccess, which allows unrestricted use of the figures).
