Table 2.
Up-regulated proteinsain AR/control urine samples compared to baseline shown for individual patients
| Rejection group | No-rejection group | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |
|
|
AR 1 |
AR 2 |
AR 3 |
AR 4 |
AR 5 |
AR 6 |
C 1 |
C 2 |
C 3 |
C 4 |
C 5 |
C 6 |
| |
|
Banff classification |
I3T1V0 C4d- |
I2T2V0 C4d- |
I2T2V0 C4d- |
I2T2V0 C4d- |
I2T3V0 C4d- |
I3T1V2 C4d- |
NA |
NA |
NA |
NA |
NA |
NA |
| IPI ID |
Gene ID |
Protein name |
Log 2 change |
Log 2 change |
||||||||||
|
Immune proteins |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| IPI00217775.1 |
CD74 |
Isoform 2 of HLA class II histocompatibility antigen gamma chain |
NDb |
0.47 |
2.57 |
4.06 |
1.81 |
1.23 |
0.39 |
1.03 |
0.81 |
0.99 |
2.10 |
0.58 |
| IPI00004573.2 |
PIGR |
Polymeric immunoglobulin receptor |
−0.04 |
0.66 |
2.27 |
1.31 |
0.36 |
2.20 |
0.29 |
0.63 |
0.71 |
1.65 |
0.19 |
0.14 |
| IPI00783987.2 |
C3 |
Complement C3 (Fragment) |
−0.17 |
3.17 |
−0.48 |
1.25 |
−5.32 |
2.64 |
−3.49 |
ND |
1.14 |
−4.80 |
−1.54 |
−3.63 |
| IPI00017601.1 |
CP |
Ceruloplasmin |
0.42 |
4.40 |
0.34 |
1.15 |
ND |
4.79 |
−1.87 |
−1.25 |
0.22 |
−1.02 |
0.53 |
−2.02 |
| IPI00306378.5 |
MASP2 |
Isoform 2 of Mannan-binding lectin serine protease 2 |
1.10 |
1.88 |
1.36 |
2.30 |
1.26 |
4.06 |
0.57 |
−3.94 |
1.94 |
1.19 |
2.44 |
0.43 |
| IPI00011302.1 |
CD59 |
CD59 glycoprotein |
−2.65 |
1.16 |
1.30 |
1.74 |
0.40 |
3.62 |
−1.52 |
2.68 |
−1.90 |
1.73 |
1.31 |
0.19 |
|
Growth factors |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| IPI00016915.1 |
IGFBP7 |
Insulin-like growth factor-binding protein 7 |
0.11 |
−0.43 |
2.40 |
1.01 |
−0.91 |
2.84 |
0.71 |
1.42 |
0.05 |
0.58 |
−0.02 |
ND |
| IPI00966866.1 |
EGF |
Epidermal growth factor |
1.71 |
3.49 |
2.15 |
0.75 |
0.97 |
ND |
0.79 |
ND |
ND |
1.51 |
0.51 |
0.13 |
| IPI00395488.2 |
VASN |
Vasorin |
1.27 |
1.11 |
ND |
0.61 |
0.05 |
2.10 |
0.96 |
−2.27 |
2.00 |
0.66 |
1.69 |
−0.81 |
| IPI00023673.1 |
LGALS3BP |
Galectin-3-binding protein |
1.01 |
0.20 |
2.62 |
1.76 |
0.61 |
3.59 |
0.26 |
1.21 |
0.03 |
1.15 |
0.32 |
0.30 |
|
Other |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| IPI00004372.3 | MEP1A | MEP1A protein (Meprin A subunit alpha) | ND | ND | 1.87 | 2.87 | 1.31 | 1.02 | ND | ND | ND | ND | ND | ND |
a Criteria for up-regulation: up-regulation (log 2 change ≥1) from baseline to AR in at least three patients in the AR-group. Proteins with higher average ratio in the control group and proteins more frequently up-regulated in the control group were excluded. b ND: Not detected.