Table 3.
Ability of markers to classify T.b. rhodesiense patients according to the presence of parasites in CSF
| Marker | p value* | AUC% (95% CI) | Cut-off | SP% (95% CI) | SE% (95% CI) |
|---|---|---|---|---|---|
|
IgM [μg/mL] |
< 0.0001 |
84.5 (73.9-95.2) |
17.8 |
85.7 (66.7-100) |
81.3 (71.9-90.6) |
|
MMP-9 [pg/mL] |
< 0.0001 |
85.2 (74.3-96) |
499.8 |
90.5 (76.2-100) |
76.6 (65.6-85.9) |
|
CXCL13 [pg/mL] |
< 0.0001 |
80.4 (69.1-91.8) |
200.3 |
90.5 (76.2-100) |
73.4 (62.5-84.4) |
|
VCAM-1 [ng/mL] |
< 0.0001 |
83.2 (73.7-92.7) |
43.9 |
76.2 (57.1-90.5) |
78.1 (67.2-87.5) |
|
B2MG [ng/mL] |
< 0.0001 |
82.0 (71.3-92.7) |
1462 |
66.7 (47.6-85.7) |
85.9 (76.6-93.8) |
|
ICAM-1 [ng/mL] |
< 0.0001 |
83.3 (73–93.6) |
4.7 |
81.0 (61.9-95.2) |
73.4 (62.5-84.4) |
|
Neopterin [nmol/L] |
< 0.0001 |
75.5 (63.9-87.1) |
69.4 |
81.0 (61.9-95.2) |
65.6 (54.7-76.6) |
|
CXCL10 [ng/mL] |
0.002 |
73.1 (59.3-86.8) |
7.5 |
47.6 (28.6-66.7) |
92.2 (84.4-98.4) |
| WBC (Cells/μL) | < 0.0001 | 87.4 (77.4-97.4) | 6.5 | 71.4 (52.4-90.5) | 95.3 (89.1-100) |
Patients without parasites detected in CSF, n=21; patients with parasite detected in CSF, n=64.
* Mann–Whitney U test.
SP% = specificity%; SE% = sensitivity%; 95% CI = 95% confidence interval.