Table 4.
Panels of markers for staging T.b. rhodesiense patients obtained through a combination of 3 molecules
| Panel | Markers | Cut-off | pAUC% (95% CI)* | SE% (95%CI)* | p value† |
|---|---|---|---|---|---|
| 1 |
CXCL10 [ng/mL] |
2.2 |
94 (89.9-97.3) |
87.3 (78.9-94.4) |
0.0001 |
| |
CXCL13 [pg/mL] |
23.3 |
|
|
0.01 |
| |
MMP-9 [pg/mL] |
499.8 |
|
|
0.01 |
| 2 |
CXCL10 [ng/mL] |
2.2 |
94 (89.9-97.3) |
87.3 (78.9-94.4) |
0.0001 |
| |
CXCL13 [pg/mL] |
23.3 |
|
|
0.01 |
| IgM [μg/mL] | 17.8 | 0.02 |
* pAUC and SE% were calculated for 100% SP.
† Comparison between the pAUC (90-100% SP) of the panel and those of the markers individually considered obtained through the Bootstrap test for two correlated ROC curves.
Both panels are positive when ≥2 molecules are above their cut-off.