Skip to main content
. 2013 Jan 31;9(1):e1002888. doi: 10.1371/journal.pcbi.1002888

Figure 2. The repressilator model (as described in [40]) and the set of possible experiments.

Figure 2

(A) Illustration of the original repressilator model. The model consists of 3 mRNA species (coloured wavy lines, labeled Inline graphic, Inline graphic and Inline graphic) and their corresponding proteins (circles shown in the same color with labels Inline graphic, Inline graphic and Inline graphic). The 3 regulatory DNA regions are not modeled explicitly but included in the mRNA production process. They are shown for illustration purpose only. (B) The ordinary differential equations which describe the evolution of the concentration of the mRNAs and proteins over time. (C) Four potential modifications of the wild-type model. For each experimental intervention the modified parameters are listed (colours are as in A). The modifications of the wild-type model consist of decreasing one or several of the parameters of the system: in sets Inline graphic, Inline graphic and Inline graphic, the regime of the parameter Inline graphic is changed; in sets Inline graphic, Inline graphic and Inline graphic, respectively, parameters Inline graphic, Inline graphic and Inline graphic are modified for only one gene which breaks the symmetry of the system.