Table 2.
Comparison of neonatal outcomes
| Outcomes | FIC infants (n = 31) | Matched controls (n = 62) | p-value1 | Percent change |
|---|---|---|---|---|
| Zwt21 – Zwt1, mean (SD) | 0.61 (0.44) | 0.49 (0.41) | 0.26 | 24.5 |
| (Wt21-Wt1)/(Wt1/1000)/21, mean (SD) | 21.59 (6.43) | 20.32 (6.59) | 0.48 | 6.25 |
| (Wt21-Wt1)/21, mean (SD) | 30.82 (9.08) | 28.25 (9.09) | 0.17 | 9.1 |
| Nosocomial infection, N (%) | 0 (0.0) | 6 (9.7) | 0.057 | -100 |
| Incidents / 1000 person days (95%CI) | 0.84 (0, 1.96) | 1.15 (0, 3.08) | 0.78 | -26.96 |
| BPD, N (%) | 11 (35.5) | 24 (38.7) | 0.54 | -8.27 |
| ROP3, N (%) | 0 (0.0) | 8 (14.3) | 0.045* | -100 |
| IVH grade 3 or 4 or PVL, N (%) | 2 (6.7) | 5 (8.3) | 0.78 | -16.87 |
| NEC, N (%) | 0 (0.0) | 2 (3.2) | 0.31 | -100 |
| Breast feeds (> 90%), n (%) | 23 (74.2) | 25 (40.3) | 0.002* | 45.7 |
Notes: Weight was measured at study enrolment and 21 days after enrolment; all other outcomes are for the period from enrolment to discharge. 1A conditional logistic regression method accounting for matched case-control data was used. The Mantel-Haeszel test was also applied for categorical data. The results from both methods were consistent. BPD, bronchopulmonary dysplasia; CI, confidence interval; FIC, family integrated care; IVH, intraventricular hemorrhage; NEC, necrotizing enterocolitis; PVL, periventricular leukomalacia; ROP3, retinopathy of prematurity, stage 3; SD, standard deviation; Wt1, weight on enrolment; Wt21, weight 21 days after enrolment; Zwt1, z-score for weight on enrolment; Zwt21, z-score for weight 21 days after enrolment.