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. 2013 Jan 18;13:25. doi: 10.1186/1471-2407-13-25

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Copyright ©2013 Pang et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MiR-34a reduces cell invasion through Notch signaling. (A) Representative images showing that Notch activation nearly fully nullified the inhibitory effect of miR-34a force-expression on cell invasion. (B) Invasion expressed as relative to the untreated control cells (n = 4). (C) Proliferation of the cells. Parallel experiment demonstrated no significant effect of treatments on proliferation of the transfected cells. (D) uPA and MMP9 mRNA expression in the transfected cells as determined by RT-qPCRs (n = 4) *p < 0.05.