Table 3.
Microbicidal effect of CEN1 HC against Gram-positive and Gram-negative bacterial strains and a yeast strain
| |
CEN1 HC MMC 99(mg/L) |
fusidic acid MMC99 (mg/L) |
mupirocin MMC99 (mg/L) |
|||
|---|---|---|---|---|---|---|
| Microorganism, strain | 0.037% BHI | 50% h.i. SWF | 0.037% BHI | 50% h.i. SWF | 0.037% BHI | 50% h.i. SWF |
|
S. aureus ATCC 12600 |
6.3 |
12.5 |
6.3 |
6.3 |
3.1 |
3.1 |
| MRSA ATCC 33591 |
6.3 |
25 |
6.3 |
6.3 |
3.1 |
3.1 |
|
S. pyogenes ATCC 12344 |
3.1 |
50 |
>200 |
>200 |
6.3 |
3.1 |
|
S. epidermidis ATCC 12228 |
3.1 |
12.5 |
6.3 |
6.3 |
3.1 |
3.1 |
|
P. acnes ATCC 6919 |
6.3 |
12.5 |
nd |
nd |
>200 |
>200 |
|
E. coli ATCC 11775 |
6.3 |
25 |
>200 |
>200 |
>200 |
>200 |
|
P. aeruginosa ATCC 15442 |
6.3 |
100 |
>200 |
>200 |
>200 |
>200 |
|
K. pneumoniae CCUG 59413 |
3.1 |
12.5 |
>200 |
>200 |
>200 |
>200 |
|
A. baumannii CCUG 58437 |
3.1 |
6.3 |
>200 |
>200 |
>200 |
>200 |
| C. albicans ATCC 64549 | 6.3 | >200 | >200 | >200 | >200 | >200 |
The substances were tested using a MMC99 SSassay in concentrations up to 200 mg/L in 0.037% BHI or 50% h.i. SWF. Peptides were added to bacterial cells in duplicate (n = 2). Data are presented as maximum values from at least two independent experiments. h.i. = heat inactivated, nd = not determined.