Table 4.
Inhibitory effects of CEN1 HC-Br, CEN1 HC, CEN1 HC (1–20) and CEN1 HC (Ser) on TNF-α and IL-6 secretion from THP-1 cells
| |
IC50 (mg/L) |
|
|---|---|---|
| Test substance | TNF-α | IL-6 |
| CEN1 HC-Br |
~4.0 |
0.0040 ± 0.053 |
| CEN1 HC |
2.2 ± 0.4 |
0.33 ± 0.14 |
| CEN1 HC (1–20) |
141.4 ± 18.4 |
9.8 ± 8.6 |
| CEN1 HC (Ser) | 6.0 ± 2.4 | nd |
Data are presented as half maximal inhibitory concentration (IC50) values ± SEM, as calculated by Origin software from dose–response curves using a 4-parameter fit. Due to an unsatisfactory curve fitting, IC50 for CEN1 HC-Br on TNF-α was estimated to approximately 4 mg/L. nd = not determined.