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. 2013 Jan 31;8(1):e55345. doi: 10.1371/journal.pone.0055345

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© 2013 Bischoff et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Combined, our results support differential cholesterol synthesis, transport and transcriptional activation in the placentae of two breeds of swine. Specifically, our results predict 1) increased cholesterol biosynthetic activity in Meishan placentae, 2) increased cholesterol efflux by transporters ABCA1 towards the fetal blood lumen in WC placentae and 3) increased gene expression by transcriptional activation of cholesterol enzymes mediated in part by SRE-binding proteins and RXR/LXR signaling in Meishan.