Table 4. Summary of Ingenuity ranked canonical (KEGG) pathways.
| Ingenuity Canonical Pathways | −log(B-H p-value) | Genes |
| Biosynthesis of Steroids | 4.12* | MVD, FDPS, FDFT1, EBP, CYP7B1, IDI1, MVK, NQO1, HMGCR, SC5DL |
| Antigen Presentation Pathway | 2.35* | HLA-DMA, HLA-DRB4, HLA-A, HLA-B, HLA-DRB1, CANX, TAP1, HLA-C |
| Glutathione Metabolism | 2.07* | MGST1, MGST2, GSTA4, GSTM3 (includes EG:2947), GSTA1, G6PD, GGT6, IDH2, GPX7, ANPEP, GSTO1 |
| LPS/IL-1 Mediated Inhibition of RXR Function | 1.94* | MGST1, GSTM3 (includes EG:2947), GSTA1, ABCB11, ACSL6, GSTO1, ABCA1, LY96, SULT4A1, GSTA4, UST, MGST2, MAP3K7, SLC27A6, FABP4, XPO1, NR5A2, LBP, PLTP, TNFRSF1B, ACOX3, HMGCS1, CYP4A11, ALDH7A1 |
| Complement System | 1.93* | C1R, C1S, CD55, C1QC, C1QA, CD46, C1QB |
| LXR/RXR Activation | 1.88* | RXRG, LY96, CCL2, FASN, ACACA, LBP, PLTP, TNFRSF1B, HMGCR, HADH, ABCA1 |
| Valine, Leucine and Isoleucine Degradation | 1.88* | HSD17B10, PCCA, ACAD8, ECH1, ELOVL2, OXCT1, AOX1, HMGCS1, HADH, ALDH7A1, MCCC2 |
| Hepatic Fibrosis/Hepatic Stellate Cell Activation | 1.82* | MYH10, CCR5, VEGFB (includes EG:7423), CTGF, MYL6, EDNRB, MMP2, COL1A2, COL1A1, LY96, CCL2, IGFBP3, LBP, TNFRSF1B, A2M, EGFR, COL3A1 |
| Caveolar-mediated Endocytosis Signaling | 1.66* | FYN, HLA-A, ACTB, CD55, ITGA2, COPA, HLA-B, ACTG1, EGFR, HLA-C, COPG |
| Arachidonic Acid Metabolism | 1.65* | TMEM87B, CYP4A22, CYP2U1, PLA2G10, PTGS1, YWHAZ, GGT6, CYP2D6, GPX7, PLOD1, CYP1B1, LAMB2, PTGES3 (includes EG:10728), MGST2, CYP19A1, CYP4B1, CYP4A11, CYP51A1 |
| Actin Cytoskeleton Signaling | 1.59* | MYH10, TIAM1, PFN1, PIK3C2A, MYL6, ARPC1B, GRB2, ACTB, GNA12, ITGA2, C3ORF10, PIKFYVE, GSN, ACTG1, PDGFC, PTK2, PAK1, TIAM2 (includes EG:26230), FGF23, PPP1R12A, DIAPH2, LBP, PDGFD, PPP1CA |
| Fatty Acid Metabolism | 1.47* | HSD17B10, CYP4A22, ACSL6, ECH1, CYP2D6, CYP1B1, CYP19A1, PECI, CYP4B1, ACAD8, SLC27A6, ACOX3, CYP4A11, HADH, CYP51A1, ALDH7A1 |
| Aryl Hydrocarbon Receptor Signaling | 1.36* | MGST1, GSTM3 (includes EG:2947), GSTA1, NQO1, SMARCA4, GSTO1, CYP1B1, RXRG, CCND2, PTGES3 (includes EG:10728), CCNA1, MGST2, GSTA4, NFIB, CDK2, ALDH7A1 |
| Type I Diabetes Mellitus Signaling | 1.32* | HLA-DMA, JAK1, ICA1, CD28, IKBKG, NFKBIA, HLA-A, MAP3K7, HLA-B, TNFRSF1B, SOCS5, CPE, HLA-C |
*
Denotes significance greater than 1.30, corresponds to –(log of Benjami-Hochberg corrected p-value <0.05.