Table 4.
KEGG pathways represented by DEGs commonly regulated by TSA and CBHA at 6 h or 24 h in H9c2 cells*
|
DEGs common to TSA and CBHA at 6h | |||
|---|---|---|---|
| KEGG pathway | Gene nos | Entrez Gene IDs | P value |
| MAPK signaling pathway |
7 |
FGF7, FGF8, MKNK2, NFAT4,TGFb3, |
P=2.02e-3 |
| |
|
CD14, MAPKI8P1 |
|
| Adipocytokine signaling pathway |
5 |
CPT1A, PEPCK, ACSL5, ADIPOR2, CAMKK1, |
P=9.51e-5 |
| Purine metabolism |
5 |
NME6, GMPR, IMPDH2, POLD3, POLR3F |
P=2.90e-3 |
| Cell cycle |
5 |
TGFb3, CUL1, CCNA2, CCNB2, CDC20 |
P=8.67e-4 |
| Phosphatidylinositol signaling system |
4 |
IMPA2, INPP4A, PIK3C2A, ITPKA |
P=1.14e-3 |
| Ubiquitin mediated proteolysis |
3 |
UBE2C, CUL1, CDC20 |
P=2.88e-3 |
| TGF-beta signaling pathway |
3 |
FST, TGFb3, CUL1 |
P=1.60e-2 |
| PPAR signaling pathway |
3 |
CPT1A, PEPCK, ACSL5 |
P=1.60e-6 |
| Pyruvate metabolism |
3 |
HAGH, PCB, PEPCK |
P=1.60e-7 |
| Inositol phosphate metabolism |
3 |
IMPA2, INPP4A ITPKA |
P=1.60e-8 |
| Tryptophan metabolism |
3 |
CYP1B1, MAOA, LCMT1 |
P=1.60e-9 |
| Pyrimidine metabolism |
3 |
NME6 ,POLD3, POLR2D |
P=1.60e-10 |
| Citrate cycle (TCA cycle) |
2 |
PC, PEPCK |
P=1.60e-11 |
| Fatty acid metabolism |
2 |
CPT1A, ACSL5, |
P=1.60e-12 |
| Glutamate metabolism |
2 |
GCLC, GLS |
P=1.60e-13 |
| Arginine and proline metabolism |
2 |
ARG2, MAOA |
P=1.60e-14 |
| Histidine metabolism |
2 |
MAOA, LCMT1 |
P=1.60e-15 |
| Tyrosine metabolism |
2 |
MAOA, LCMT1 |
P=1.60e-16 |
| Selenoamino acid metabolism |
2 |
SEPHS2, LCMT1 |
P=1.60e-17 |
| Glutathione metabolism |
2 |
GCLC, MGST3 |
P=1.60e-18 |
|
DEGs common to TSA and CBHA at 24h | |||
| Cell cycle |
12 |
MCM4, MCM3, MCM6 MCM7, PLK1, BUB1B, |
P=1.74e-14 |
| |
|
BUB1 CCNA2, CCNB2 PKMYT1 CDC6, CDC20 |
|
| Glutathione metabolism |
6 |
GPX7, GST4, GSTM1, GSTP1, GCLC, MGST3 |
P=1.15e-8 |
| Metabolism of xenobiotics by cytochrome P450 |
5 |
MGST1, GST4, GSTM1, GSTP1, MGST3 |
P=2.76e-6 |
| Pyrimidine metabolism |
4 |
POLD1, POLE2, RFC5, RRM2 |
P=3.95e-4 |
| Purine metabolism |
4 |
POLD1, POLE2, RFC5, RRM2 |
P=2.48e-3 |
| DNA polymerase |
3 |
POLD1, POLE2, RFC5 |
P=1.20e-4 |
| ECM-receptor interaction |
2 |
HMMR, LAMC2 |
P=3.99e-2 |
| Ubiquitin mediated proteolysis | 2 | UBE2C, CDC20 | P=1.19e-2 |
*The KEGG pathways associated with the common gene set affected by TSA or CBHA at 6h and 24h post-treatment in H9c2 cells are hierarchically arranged based on the number of common DEGs and the significance of enrichment (p value) derived as described in “Material and Methods”.