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. 2013 Jan 31;8(1):e55509. doi: 10.1371/journal.pone.0055509

Figure 8. Imatinib promotes p65 nuclear translocation and inhibits NF-κB target expression in a STAT3-dependent manner.

Figure 8

(A) 435s/M14 cells, transfected with STAT3 siRNA, were drug treated (8 h), and nuclear fractions analyzed by Western blot. Graph is Mean±SEM from 3 independent experiments. (B) 435s/M14 cells stably expressing pcDNA or STAT3C were drug treated (8 h), and nuclear fractions analyzed by Western blot. Graph is Mean±SEM of 3 independent experiments. (C) Lysates from drug-treated pcDNA and STAT3C-expressing cells (40 h), were analyzed by Western blot. Graphs are Mean±SEM from 3 independent experiments. For all subfigures, some error bars are too small to visualize. *p<0.05, **p≤0.01 (see methods).