. 2013 Jan 31;8(1):e55558. doi: 10.1371/journal.pone.0055558

Table 1. Total biofilm weight and microbiological colony count of total microbiota and Candida spp. according to treatments (amoxicillin/clavulanate potassium or placebo) and daily frequency of sucrose exposure (0 – no exposure; exposure – 3 or 8 times/day).

Treatment	Sucrose Exposure (times/day)	Total Biofilm Weight (wet weight in mg)	Candida spp CFU×10⁶/mg biofilm	Total Microbiota CFU×10⁶/mg biofilm
Amoxicillin/Clavulanate Potassium	0	3.00 (0.60–16.10)^a,A	0.42 (0.002–7.81)^a,A	3.86 (0.02–53.13)^a,A
	3	5.30 (1.00–66.00)^a,B	0.51 (0.00004–6.50)^a,A	1.39 (0.36–27.08)^a,A
	8	14.50 (5.70–55.60)^a,B	1.58 (0.06–9.79)^a,A	3.41 (0.36–46.74)^a,A
Placebo	0	5.90 (0.90–32.10)^a,A	0.67 (0.006–2.38)^a,A	7.50 (0.02–50.00)^a,A
	3	7.50 (0.70–76.20)^a,A	0.26 (0.0002–5.00)^a,A	3.19 (0.06–24.29)^a,A
	8	9.40 (1.00–83.80)^a,A	0.86 (0.0003–4.06)^b,A	2.71 (0.04–72.50)^a,A

Results are expressed as median (minimum – maximum values) – n = 11.

CFU: colony-forming units.

Distinct lower-case superscript letters indicate statistical significance for the comparison between treatments within each frequency of sucrose exposure (p<0.05; Wilcoxon Signed-Rank test).

Distinct capital superscript letters indicate statistical significance for the comparison among different frequencies of sucrose exposure within each treatment (p<0.05 – Friedman test; p<0.017 – Post-hoc analysis with Wilcoxon Signed-Rank Tests conducted with a Bonferroni correction).