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. 2013 Jan 31;8(1):e55683. doi: 10.1371/journal.pone.0055683

Figure 1. Different GFAP expression between retina and optic nerve after the induction of transient intraocular hypertension.

Figure 1

(A) HE staining showed that comparing with the intact and regular retina in control rats, transient intraocular hypertension induced significant decrease in the thickness of retina as early as 3 days. (B) In control retina, GFAP immunoreactivity was confined to the nerve fiber layer (NFL) and ganglion cell layers. Three days after the induction of transient intraocular hypertension, GFAP-labeled processes were found to enwrap the RGCs and extend throughout the entire retina. (C–D) Immunoblots revealed increased expression of GFAP in the retina at 1, 2, 3, and 7 days after the injury. (E–F) While in the optic nerve, the expression of GFAP seemed to be constant throughout the observation course. * p<0.05; ** p<0.01.