Figure 2. Comparison of C. gattii isolates and interspecies hybrids with C. neoformans isolates and hybrids between both C. neoformans varieties.

The forty heat-killed Cryptococcus isolates are grouped according to (sub)species. Cytokine production by human PBMCs after 24 h (IL-1β, TNF-α, IL-6 and IL-1Ra) and 7 d (IL-17 and IL-22) incubation is shown. Mean values (n = 5 to 7) ± SE of three independent experiments are presented. *, p 0.01 to 0.05; **, p 0.001 to 0.01; ***, p<0.001. The horizontal line represents the lower detection limit.