Table 1. Top 10 list of canonical pathways activated by VCP-interacting proteins from Ingenuity Pathway Analysis.

Ingenuity Canonical Pathways	#of gene	Molecules	−log(p-value)
PI3K/Akt Signaling	18	AKT1, BAX, ERK1/2, Hsp90, HSP90AB1, MDM2, mTOR, NFKB2, PDCD4, P38 MAPK, p85 (pik3r), PI3K (complex), PP2A, Raf, Ras, TP53, 14-3-3 protein	5.89E00
Protein ubiquitination pathway	9	26 s Proteasome, Hsp27, Hsp70, Hsp90, HSP90AB1, HSPA8, HSPA1A/HSPA1B, HSPA1L, Ubiquitin	5.3E00
Aldosterone signaling in epithelial cells	13	ERK1/2, Hsp27, Hsp70, Hsp90, HSP90AB1, HSPA8, HSPA1A/HSPA1B, HSPA1L, P38 MAPK, p85 (pik3r), PI3K (complex), Raf, Ras	4.71E00
Glycolysis/gluconeogenesis	9	AKT1, ERK1/2, G-protein beta, GNB2L1, P38 MAPK, p85 (pik3r), PI3K (complex), Raf, Ras	4.51E00
p70S6K signaling	10	AKT1, ERK1/2, G protein alphai, P38 MAPK, p85 (pik3r), PI3K (complex), PP2A, Raf, Ras, RPS6	3.9E00
Glucocorticoid receptor signaling	14	AKT1, Histone h3, Hsp70, Hsp90, HSP90AB1, HSPA8, HSPA1A/HSPA1B, HSPA1L, Jnk, P38 MAPK, p85 (pik3r), PI3K (complex), Pka, Rac	3.62E00
Mitotic roles of Polo-like kinase	6	AKT1, Jnk, P38 MAPK, p85 (pik3r), PI3K (complex), Ras	3.55E00
Hypoxia signaling in the cardiovascular system	6	AKT1, Creb, Hsp90, HSP90AB1, PI3K (complex), TP53	3.41E00
ERK/MAPK signaling	5	Creb, Histone h3, Hsp27, Jnk, P38 MAPK	3.16E00
14-3-3 protein-mediated signaling	8	AKT1, Alpha tubulin, ERK1/2, Gamma tubulin, TUBA1A, TUBB, TUBB2C, VIM	2.71E00