Figure 1. Pedigrees of the families in which multiple tumours showed the “22-gain-like” aCGH profile.

Individuals affected with breast cancer are represented by a filled square or circle. Individuals affected by another type of cancer are represented by a square or circle with a vertical black stripe. Below the age at diagnosis and type of cancer can be found: B stands for breast cancer, Li or liver cancer, S for stomach cancer, Oes for oesophagus cancer, C for colon cancer, M for melanoma, Cvx for Cervix cancer, K for kidney cancer, P for prostate cancer and U for type of cancer unknown. Arrows point at the individuals at whose DNA was used for exome sequence. Individuals with tumours with and without the “22-gain-like profile” are represented by “22+”and “22−”.