Figure 2. Linkage on chromosome 4 for the families in which multiple tumours showed the “22-gain-like” aCGH profile.

The LOD-score was calculated under the assumption of homogeneity. The dashed lines indicate the maximum LOD-score -1interval. The X-axis shows the position on chromosome 4 in centimorgan and the markers with a LOD score >0 are indicated. The highest LOD score of 2.49 was located at marker D4S405.