Table 2. Univariate analyses of DFS and OS according to the expression of CD31 and nucleolin in all patients and subgroups with clinicopathologic variables (Log-rank test).
Surface expression | No. of patients (%) | DFS (5-year) | OS (5-year) | ||
(%) | P value | (%) | P value | ||
Total | |||||
CD31loNCLlo | 52 (35.7) | 64 | 72 | ||
CD31hiNCLlo | 44 (30.1) | 50 | 65 | ||
CD31hiNCLhi | 50 (34.2) | 24 | 0.002 | 69 | 0.841 |
Histology | |||||
ADC* | |||||
CD31loNCLlo | 25 (29.1) | 57 | 71 | ||
CD31hiNCLlo | 31 (36.0) | 47 | 62 | ||
CD31hiNCLhi | 30 (34.9) | 21 | 0.061 | 73 | 0.837 |
SCC‡+ADSCC§ | |||||
CD31loNCLlo | 27 (45) | 70 | 73 | ||
CD31hiNCLlo | 13 (21.7) | 56 | 69 | ||
CD31hiNCLhi | 20 (33.3) | 27 | 0.028 | 64 | 0.805 |
Tumor differentiation | |||||
Low | |||||
CD31loNCLlo | 26 (40.6) | 46 | 64 | ||
CD31hiNCLlo | 16 (25) | 42 | 56 | ||
CD31hiNCLhi | 22 (34.4) | 8 | 0.038 | 57 | 0.782 |
Median, High | |||||
CD31loNCLlo | 26 (31.8) | 82 | 80 | ||
CD31hiNCLlo | 28 (34.1) | 54 | 70 | ||
CD31hiNCLhi | 28 (34.1) | 35 | 0.01 | 79 | 0.873 |
Tumor size | |||||
<5 cm | |||||
CD31loNCLlo | 36 (39.1) | 73 | 74 | ||
CD31hiNCLlo | 30 (32.6) | 56 | 76 | ||
CD31hiNCLhi | 26 (28.3) | 24 | 0.008 | 85 | 0.843 |
≥5 cm | |||||
CD31loNCLlo | 16 (29.6) | 43 | 69 | ||
CD31hiNCLlo | 14 (25.9) | 37 | 39 | ||
CD31hiNCLhi | 24 (44.5) | 26 | 0.392 | 51 | 0.795 |
Overall stage | |||||
Stage I | |||||
CD31loNCLlo | 26 (40.6) | 91 | 88 | ||
CD31hiNCLlo | 17 (26.6) | 74 | 94 | ||
CD31hiNCLhi | 21 (32.8) | 25 | <0.001 | 90 | 0.474 |
Stage II∼III | |||||
CD31loNCLlo | 26 (31.7) | 37 | 55 | ||
CD31hiNCLlo | 27 (32.9) | 35 | 45 | ||
CD31hiNCLhi | 29 (35.4) | 24 | 0.374 | 54 | 0.825 |
Treatment | |||||
Surgery alone | |||||
CD31loNCLlo | 34 (39.5) | 69 | 73 | ||
CD31hiNCLlo | 20 (23.3) | 61 | 67 | ||
CD31hiNCLhi | 32 (37.2) | 29 | 0.015 | 78 | 0.969 |
Surgery+other(s) | |||||
CD31loNCLlo | 18 (30) | 56 | 71 | ||
CD31hiNCLlo | 24 (40) | 39 | 63 | ||
CD31hiNCLhi | 18 (30) | 14 | 0.088 | 56 | 0.619 |