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(ctnnb1) and ctnnb1Δex3 strongly activates the TOP promoter. The empty, ctnnb1 and ctnnb1Δex3 expression vectors were co-transfected with TOP (black) and FOP (white) vectors in B16 melanoma cell lines [37]. Similar results were obtained with normal murine melanocytes (melan-a cells). The experiments were performed 3 times. *: p-value <0.05, **: p-value <0.01.
