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. 2013 Jan 31;8(1):e53183. doi: 10.1371/journal.pone.0053183

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© 2013 Yajima et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Ultrasound analysis showing an open Tyr::Cre; ctnnb1Δex3/+ (ctnnb1Δex3) DA. (B) Enlargement of (A) showing the DA. (C) Ultrasound analysis of a ctnnb1Δex3 patent foramen ovale. (D) Shunting through the foramen ovale as observed by echo Doppler analysis in ctnnb1Δex3 mice. (E) The foramen ovale remains open in ctnnb1Δex3 hearts. Note the presence of pigmented cells. LA: left atrium, RA: right atrium, Ao: aorta, RVOT: right ventricle outflow tract, DA: ductus arteriosus.