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. 2013 Jan 31;8(1):e55212. doi: 10.1371/journal.pone.0055212

Figure 2. Current-voltage relationships of wild type and mutant Nav1.7 channels.

Figure 2

(A) Representative current traces showed no apparent differences between wild type and mutant channels. (B–D) The current-voltage curves showed a hyperpolarizing shift in activation in all mutant (empty circles) channels without shifting in reversal potential as compared with wild type (solid squares). (E–G) The half maximal activation potential (activation V1/2) of each channel (mutant channel, empty circle and wild type channel, solid square). (H) The activation V1/2 of wild type channel is about −25.88 mV, but −35.32 mV for I136V, −30.84 mV for I848T, and −32.68 mV for V1316A mutant channel. (I) V1316A mutant channel shows an increase in slope factor and no difference in I136V and I848T mutant channels as compared with wild type. *P<0.05, ***P<0.001 vs. wild type; t-test; data shown as means ± SEM.