Skip to main content
. 2013 Jan 31;8(1):e55212. doi: 10.1371/journal.pone.0055212

Figure 7. Lidocaine IC50 curves of wild type and mutant Nav1.7 channels.

Figure 7

(A-D) Lidocaine IC50 curves of wild type, I136V, I848T, and V1316A mutant Nav1.7 channels, respectively. The IC50 value of wild type channel for lidocaine is 1.31±0.87 mM. All the mutant channels reveal significant higher IC50 values (I136V: 3.95±1.58 mM**; I848T: 3.11±0.48 mM*; V1316A: 7.92±2.50 mM***) compared with wild type. N for wild type is 5, I136V, 7, I848T, 3, V1316A, 4; *P<0.05, **P<0.01, ***P<0.001 vs. wild type; t-test; data shown as means ± SEM.