Figure 7. TNF signaling is affected in HeLa cells treated with Cas II-gly favoring apoptosis rather than differentiation and proliferation.

Image based in an analysis of the gene expression matrix in the Ingenuity® database for Systems Pathways Analysis (IPA) [28]. Molecules in green are transcriptionally down-regulated whereas molecules in red are transcriptionally over-expressed. Notice the abundance of molecules -such as HMOX1- responding to oxidative stress.