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. 2013 Jan 31;8(1):e54664. doi: 10.1371/journal.pone.0054664

Table 1. Statistically Significant Enrichment of Gene Ontology Categories for differentially expressed genes in HeLa cells treated with Cas II-Gly.

GO-ID FDR-corrected p-value Genes in test set
16265 3.85E-07 death
8219 3.85E-07 cell death
6915 1.00E-06 apoptosis
12501 1.00E-06 programmed cell death
42981 4.88E-05 regulation of apoptosis
43067 4.88E-05 regulation of programmed cell death
7050 6.19E-05 cell cycle arrest
8632 7.96E-05 apoptotic program
22402 1.08E-04 cell cycle process
6917 1.08E-04 induction of apoptosis
12502 1.08E-04 induction of programmed cell death
6950 1.20E-04 response to stress
6974 1.20E-04 response to DNA damage stimulus
43065 2.94E-04 positive regulation of apoptosis
43068 2.98E-04 positive regulation of programmed cell death
7049 6.50E-04 cell cycle
185 8.90E-04 activation of MAPKKK activity
46902 8.90E-04 regulation of mitochondrial membrane permeability
8629 9.46E-04 induction of apoptosis by intracellular signals
8625 3.19E-03 induction of apoptosis via death domain receptors
8630 7.99E-03 DNA damage response, signal transduction resulting in induction of apoptosis
30262 8.29E-03 apoptotic nuclear changes
7006 8.29E-03 mitochondrial membrane organization and biogenesis
8633 8.29E-03 activation of pro-apoptotic gene products
43123 9.35E-03 positive regulation of I-kappaB kinase/NF-kappaB cascade
8624 1.84E-02 induction of apoptosis by extracellular signals
6919 1.86E-02 caspase activation
43280 2.03E-02 positive regulation of caspase activity
42770 2.03E-02 DNA damage response, signal transduction
43618 2.57E-02 regulation of transcription from RNA polymerase II promoter in response to stress
43619 2.57E-02 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
43620 2.57E-02 regulation of transcription in response to stress
41 3.28E-02 transition metal ion transport
43066 3.45E-02 negative regulation of apoptosis
43069 3.56E-02 negative regulation of programmed cell death
51881 4.12E-02 regulation of mitochondrial membrane potential
8635 4.12E-02 caspase activation via cytochrome c
279 4.70E-02 M phase
42771 4.97E-02 DNA damage resp., signal transduction by p53 class mediator; induction of apoptosis