Table 3. Top 20 GSEA - Cancer Modules for differentially expressed genes in HeLa cells treated with Cas II-Gly.

Module	FDR corrected p-val	Relevant features
MODULE_235	0.006254237	Phase II conjugation - metabolic detoxification
MODULE_164	0.003127119	p53 signaling pathway,
MODULE_6	0.007922776	Cell adhesion, functionalization of compounds
MODULE_247	0.020577544	Genes involved in Biological oxidations
MODULE_488	0.020014847	Cell Cycle: G1/S Check Point, local acute inflammatory response
MODULE_263	0.018957132	NOD-like receptor signaling pathway (NF-KB related)
MODULE_108	0.022294335	Selective expression of chemokine receptors during T-cell polarization
MODULE_178	0.028853938	Genes involved in PI-3K cascade
MODULE_362	0.026101848	Genes involved in Signaling by VEGF
MODULE_444	0.028056284	Genes involved in SHC-mediated cascade, regulation of cell adhesion
MODULE_14	0.026060386	Cytokine Network
MODULE_29	0.02646123	GTP hydrolysis
MODULE_516	0.025891503	Regulation of cell adhesion
MODULE_83	0.026049469	Cytochrome c oxidase activity
MODULE_76	0.02518265	Toll-like receptor signaling pathway, NOD-like receptor signaling pathway
MODULE_462	0.02532188	Genes involved in Biological oxidations, Phase II conjugation - metabolic detoxification
MODULE_151	0.02696601	Oxidoreductase activity, mitochondrial membrane, cytochrome c oxidase activity
MODULE_355	0.025467897	Stress Induction of HSP Regulation, p38 MAPK Signaling Pathway
MODULE_93	0.02453315	Oxidoreductase activity, metal ion transporter activity, glutathione peroxidase activity
MODULE_5	0.032609396	Response to stress, inflammatory response, protein kinase activity

Statistical significance was assessed by hypergeometric tests, corrected with the false discovery rate (FDR) algorithm.