Table 1. Summary of urine data from mice receiving different treatments.
pH | Volume/BW (g/g) | PO4/creatinine (mM/mg/dl) | NH4 +/creatinine (mM/mg/dl) | Na+/creatinine (mM/mg/dl) | K+/creatinine (mM/mg/dl) | Cl−/creatinine (mM/mg/dl) | |
Control 1 | 6.19±0.08 | 0.04±0.01 | 1.00±0.15 | 0.77±0.19 | 1.97±0.21 | 4.66±0.28 | 4.56±0.51 |
NH4Cl | 5.48±0.02*** | 0.04±0.01 | 0.61±0.17 | 6.54±0.81** | 2.57±0.33 | 5.54±0.51 | 11.68±1.61** |
NaHCO3+DOCA | 8.48±0.15*** | 0.10±0.03 | 0.62±0.21 | 0.08±0.03*** | 15.28±2.01*** | 3.83±0.52 | 3.84±0.36 |
NaCl | 6.30±0.14 | 0.09±0.02 | 0.79±0.11 | 0.25±0.02** | 11.34±0.89*** | 3.93±0.48 | 17.08±2.18*** |
Control 2 | 6.28±0.08 | 0.04±0.01 | 0.93±0.14 | 0.42±0.02 | 2.23±0.16 | 6.30±0.44 | 4.44±0.39 |
DOCA | 6.52±0.02* | 0.05±0.01 | 1.10±0.14 | 0.77±0.06*** | 2.88±0.22* | 7.72±0.31* | 5.80±0.17** |
Control 3 | 6.34±0.07 | 0.09±0.01 | 1.41±0.13 | 0.42±0.03 | 2.71±0.34 | 9.34±1.11 | 5.17±0.65 |
NaHCO3 | 8.29±0.18*** | 0.05±0.01 | 0.93±0.10* | 0.06±0.01*** | 13.12±0.47*** | 6.47±0.40 | 3.87±0.30 |
Control 4 | 6.00±0.13 | 0.05±0.00 | 0.94±0.06 | 0.79±0.20 | 1.34±0.05 | 5.19±0.33 | 3.59±0.27 |
KCl | 5.75±0.17 | 0.12±0.03* | 1.36±0.12* | 0.66±0.16 | 3.15±0.28*** | 29.70±4.07*** | 24.96±4.97** |
KHCO3 | 8.11±0.09*** | 0.10±0.01** | 1.07±0.16 | 0.23±0.13* | 1.97±0.34 | 20.21±2.48*** | 4.56±0.60 |
All animals were treated for 7 days and placed into metabolic cages for the final 3 days. Urine analysis was performed from samples collected under mineral oil over the last 24 hrs. Values are means ± SE; n = 5–7/group. Shown is a summary of urinary data from all different treatment groups and the corresponding controls. BW, body weight, crea creatinine.
p<0.05,
p<0.01,
p<0.001.