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. 2013 Jan 31;8(1):e55269. doi: 10.1371/journal.pone.0055269

Figure 3. Plasma collected from Plasmodium falciparum infected women in early pregnancy inhibits Swan cell migration at 6 h (A) and 24 h (B).

Figure 3

Median (IQR) percent increase in migration (relative to 0 h) of Swan 71 cells was measured over 24 h in response to control treatments (10% fetal bovine serum [FBS] in serum free medium, untreated [SFM], and 500 ng/ml LPS in SFM, open bars) or with 10% plasma from individuals (black bars) that were malaria-uninfected (n = 13), P. vivax-infected (n = 9) or P. falciparum-infected (n = 13), over 4 independent experiments. (A) At 6 h, plasma collected from women with P. falciparum infection inhibited migration compared with plasma from uninfected women (*P = .01). Treatment with LPS significantly inhibited migration (*P = .03) compared with 10% FBS treatment. There was no difference between uninfected and P. vivax plasma treatments (P = .35). (B) At 24 h, compared with cells treated with uninfected plasma, plasma collected from women with P. falciparum infection significantly reduced migration (**P = .004), while migration with plasma from P. vivax infection was unchanged (P = .64). LPS significantly inhibited migration compared to cells treated with 10% FBS (*P = .03).