Standard dosage |
Ubiquinol doses of 2 to 8 mg/kg per day (administered twice daily with meals) seem prudent; this form of CoQ10 in a solubilized, bioavailable form is preferred over ubiquinone. Ubiquinone doses of 5 to 30 mg/kg per day (administered in two divided doses daily with meals) is an available alternative. |
Contraindications |
None known. |
Main drug interactions |
May lower warfarin concentrations. |
Main side effects |
Wakefulness. |
Special points |
CoQ10 has been approved by the US Food and Drug Administration (FDA) for treatment of mitochondrial disease. Although animal and human experience with CoQ10 treatment has shown no toxicity, it is not known whether supratherapeutic blood levels are safe. Pro-oxidant and physiologic signaling roles of CoQ are a concern [18]. |
Cost/cost-effectiveness |
CoQ treatment is expensive (about $200/mo for 400 mg/d of ubiquinol). However, the prevalent expert view is that CoQ supplemental theraphy is beneficial in mitochondrial disease. |