Table 1.
Chronological summaries of the experimental procedures are shown: vaccine administration (V), blood collection (B), acute methamphetamine challenges (doses), and surgery (Experiment 2 only). Experiment 1 investigated effects of vaccination with MH2(R), MH6, MH7, and KLH (control) on rectal temperature and wheel activity in rats at TA = 27±1°C. Experiment 2 investigated effects of vaccination with MH6 and KLH (control) on body temperature and locomotor activity in rats at TA = 23±1°C.
| Experiment 1 | Experiment 2 | ||||||
|---|---|---|---|---|---|---|---|
| Week | Vaccine (V) | Blood (B) | METH (doses) | Week | Vaccine (V) | Blood (B) | METH (dose) |
| 0 | V (Prime) | 0 | V (Prime) | ||||
| 1 | B | 1 | |||||
| 2 | V (Boost 1) | B | 2 | V (Boost 1) | B | ||
| 3 | B | 3 | Surgery | ||||
| 4 | B | 4 | B | 0.0, 1.0, 5.6 mg/kg | |||
| 5 | V (Boost 2) | B | 5 | V (Boost 2) | |||
| 6 | B | 6 | B | ||||
| 7 | B | 7 | 0.0, 1.0, 5.6 mg/kg | ||||
| 8 | B | 8 | B | ||||
| 9 | V (Boost 3) | B | 9 | V (Boost 3) | |||
| 10 | B | 10 | B | ||||
| 11 | B | 1.0, 5.6 mg/kg | 11 | ||||
| 12 | B | 1.0, 5.6 mg/kg | 12 | B | 0.0, 0.5, 1.0, 3.2, 5.6 mg/kg | ||
| 13 | 0.0, 0.5, 1.0, 3.2, 5.6 mg/kg | ||||||
| 14 | B | ||||||
| 15 | |||||||
| 16 | B | ||||||
| 17 | |||||||
| 18 | B | ||||||
| 19 | |||||||
| 20 | B | 3.2 mg/kg | |||||