. Author manuscript; available in PMC: 2013 Jul 31.
Published in final edited form as: Nature. 2012 Dec 23;493(7434):684–688. doi: 10.1038/nature11738
Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms