Table 1.

Structures and reactivation rates, k_obs (for reactivation of VX-hAChE, sarin-hAChE, cyclosarin-hAChE and paraoxon-hAChE conjugates) by close structural analogues of RS194B at 0.67 mM concentration. Reactivation rates for each oxime are listed as an average of four k_obs values determined individually for each of the four OP-hAChE conjugates. Values are shown relative to 2PAM k_obs values. All experiments were performed at 37 °C in 0.1M phosphate buffer pH 7.4.

Oxime		kobs	Oxime		kobs
RS41A		0.88	RS2-140B		0.080
RS194B		2.5	RS2-148B		0.32
RS2-99B		0.0	RS283A		0.027
RS2-103B		1.2	RS292A		0.0060
RS2-162B		0.15	RS275D		0.16