Table 4.
Treatment of OP exposed mice with oxime RS194B. In therapy mice were administered i.m. with 125 mg/kg RS194B (+ atropine) 1 min after s.c. administration of OP. In the combined treatment mice were pretreated with 125 mg/kg RS194B i.m. 15 min before OP and then administered with another 125 mg/kg RS194B (+ atropine) 1 min after s.c. administration of OP. Protective index is the ratio of LD50 values for OP exposed animals with and without oxime treatment. Modified from (7).
| Treatment | Protective index
|
||||
|---|---|---|---|---|---|
| VX | Sarin | Paraoxon | Soman | Tabun | |
| Therapy | 18 | 10 | 9.4 | 1.8 | 1.5 |
| Pretreatment + Therapy | 45 | 4.5 | 22 | 2.8 | 2.0 |