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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Cytokine Growth Factor Rev. 2012 Oct 25;24(2):123–131. doi: 10.1016/j.cytogfr.2012.09.002

Figure 5.

Figure 5

Proposed mechanism for SNAG domain-mediated transcriptional repression. Zinc fingers bind to promoter and SNAG domain interacts with Ajuba, which can recruit PRMT5, MEP50 and HDAC to condense local chromatin structure and prevent transcription initiation (see text for details).