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Knockdown of ΔNp63 sensitizes tumor cells to arsenic treatment. A, Western blot analysis was performed with extracts from ME-180 cells that were transfected with scrambled siRNA or siRNA against p63 for 1 day and then untreated or treated with 7.5 μm arsenic trioxide for 2 days. The blots were then probed with antibodies against p63 and actin, respectively. B, ME-180 cells were treated as in A. The survival cells were collected and counted. *, p < 0.05.
