FIGURE 1.

Thrombin-cleaved fragments of OPN significantly increased in both GBM CSF and tissue. A, CSF samples from GBM patients (n = 29) were compared with CSF samples from non-GBM (n = 20), systemic cancer (n = 14), and noncancer patients (n = 15) for levels of OPN-FL (○), OPN-R (□), and OPN-L (▵). Bars represent the mean value of each group. Each point represents CSF from an individual patient. B, fraction of cleaved OPN was significantly increased in GBM and epilepsy samples compared with noncancer samples. Data were calculated from the results shown in A and shown as mean ± S.E. *, p < 0.05. C, levels of OPN-FL (●), OPN-R (■), and OPN-L (▴) in epileptic and GBM tissues determined by ELISA (n = 5 each).