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. 2012 Dec 20;288(5):3477–3488. doi: 10.1074/jbc.M112.419150

FIGURE 3.

FIGURE 3.

Lipoprotein clearance, triglyceride synthesis, and lipid mobilization in CnAβ−/− and CnAβ+/+ mice. A, triglyceride accumulation in CnAβ−/− and CnAβ+/+ mice (n = 6) was determined upon injection of Triton WR1339 (500 mg/kg), which inhibits lipid clearance. The levels of triglyceride were determined at the times indicated and presented. B, mRNA in liver of 8-week-old CnAβ−/− and CnAβ+/+ mice (n = 6) were amplified by quantitative RT-PCR to determine the expression of key SREBP target genes involved in de novo triglyceride/cholesterol synthesis. The number of cycles required to reach threshold was represented as relative mRNA expression. Fold difference of 1 is equivalent to 2-fold change. *, p < 0.05; #, p < 0.005. C and D, the levels of triglyceride (C) and free fatty acids (FFA; D) of CnAβ−/− and CnAβ+/+ mice (n = 6) upon fasting were determined at the times indicated.