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. 2012 Dec 13;288(5):3500–3511. doi: 10.1074/jbc.M112.394510

FIGURE 6.

FIGURE 6.

Metabolic basis of NAMPT inhibition in cancer cells. NAMPT inhibition affects glycolysis, the pentose phosphate, serine biosynthesis, and the TCA cycle. The affected metabolites are highlighted as either red (increased) or green (decreased). The blockade of the glyceraldehyde 3-phosphate dehydrogenase (G3PDH) step is indicated (red X). The abbreviations used are as follows: HK, hexokinase; PGI, phosphoglucose isomerase; PFK, phosphofructose kinase; TPI, triose phosphate isomerase; PGK, phosphoglycerate kinase; PGM, phosphoglycerate mutase; PKM2, pyruvate kinase 2; LDH, lactate dehydrogenase; G6PDH, glucose 6-phosphate (G6P) dehydrogenase; 6PGLA, 6-phosphogluconolactonase; Gn6PDH, 6-phosphogluconate (Gn6P) dehydrogenase; NMNAT, nicotinamide mononucleotide adenine (NMN) transferase; 3PGDH, 3-phosphoglycerate (3PG) dehydrogenase; PSAT, phosphoserine (p-ser) aminotransferase; PSPH, phosphoserine phosphatase; SHMT, serine hydroxymethyltransferase; ACC, acetyl-CoA carboxylase; ACL, ATP citrate lyase; CS, citrate synthase; IDH, isocitrate dehydrogenase; GDH, glutamate dehydrogenase; α-KGDH, α-ketoglutarate (α-KG) dehydrogenase; SDH, succinate dehydrogenase; FH, fumarate hydratase; MDH, malate dehydrogenase; PDH, pyruvate dehydrogenase; F6P, fructose 6-phosphate; F16BP, fructose 1,6-bisphosphate; 13BPG, 1,3-bisphosphoglycerate; 2PG, 2-phosphoglycerate; PEP, phosphoenolpyruvate; 6PGL, 6-phosphogluconolactone; E4P, erythrose 4-phosphate; xylulose5P, xylulose 5-phosphate; ribose5P, ribose 5-phosphate; ribulose5P, ribulose 5-phosphate; THF, tetrahydrofolate; MTHF, 5,10-methylenetetrahydrofolate; 3PHP, 3-phosphohydroxypyruvate; NAM, nicotinamide.