FIGURE 7.

Uptake of OC substrates in WT and Pmat^−/− mouse CPs. Ex vivo uptake in CPs isolated from WT and Pmat^−/− mice was conducted as described under “Experimental Procedures.” A, CP uptake rates were determined for the OC substrates MPP⁺, 5-HT, and dopamine (DA) in the absence or presence of saturating concentrations (20 mm) of unlabeled substrates (indicated by +Cold). B, CP uptake rates were determined for MPP⁺ with or without the inhibitors D22 (10 μm) and corticosterone (50 μm). The results represent the means ± S.D. of three independent experiments. *, p < 0.05 compared with WT CP; #, p < 0.05 compared with no inhibitor control.