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Plaque formation by Cx32WT and mutants at the Arg75 position. Neuro2a cells were transfected with DNA coding for the noted forms of Cx32 and stained with mouse anti-connexin antibodies in conjunction with an Alexa Fluor 594 secondary. As shown, Cx32WT and all studied mutants except R75W show elongated puncta at intercellular appositions (arrows), consistent with gap junction plaques. Note that the expression level for the R75W mutant is very low. Scale bar, 15 μm.
