Table 5.
Odds ratio (95%CI) of stroke in men and women with IL-18 values in the higher tertiles compared to the lower tertile of the distribution (n = 727A).
| IL-18 | Stroke cases | stroke controls | OR (95%CI) with adjustments |
||
|---|---|---|---|---|---|
| Tertiles | Model 1b | Model 2c | Model 3c | ||
| Full sample n = 727 | |||||
| Range (pg/mL) | |||||
| 455–2500 | 83 | 157 | 1.24 (0.84, 1.84) | 1.07 (0.71, 1.61) | 1.09 (0.72, 1.67) |
| 330–454 | 82 | 169 | 1.14 (0.77, 1.68) | 1.11 (0.73, 1.69) | 1.07 (0.71, 1.61) |
| 10–329 | 70 | 166 | 1 | 1 | 1 |
| Total | 235 | 492 | P = 0.287 | p = 0.626 | p = 0.685 |
| Continuous 1 log2 (IL-18)B | 299 | 596 | 1.26 (0.84, 1.89) | 1.13 (0.74, 1.74) | 1.11 (0.72, 1.71) |
| Sample excluding pre-existing CVD (n = 594) | |||||
| Range (pg/mL) | |||||
| 455–2500 | 54 | 132 | 1.11 (0.71, 1.75) | 1.03 (0.64, 1.67) | 1.02 (0.63, 1.64) |
| 330–454 | 62 | 144 | 1.17 (0.75, 1.82) | 1.09 (0.69, 1.73) | 1.10 (0.70, 1.74) |
| 10–329 | 54 | 148 | 1 | 1 | 1 |
| Total | 170 | 424 | P = 0.640 | p = 0.894 | p = 0.949 |
| Continuous 1 log2 (IL-18)B | 170 | 424 | 1.03 (0.74, 1.44) | 0.96 (0.67, 1.37) | 0.94 (0.66, 1.35) |
| Sample with pre-existing CVD (n = 133) | |||||
| Range (pg/mL) | |||||
| 455–2500 | 29 | 25 | 1.94 (0.37, 2.41) | 1.94 (0.61, 6.13) | 1.97 (0.62, 6.33) |
| 330–454 | 20 | 25 | 1.50 (0.60, 3.72) | 1.33 (0.44, 4.04) | 1.35 (0.44, 4.16) |
| 10–329 | 16 | 18 | 1 | 1 | 1 |
| Total | 65 | 68 | P = 0.331 | p = 0.246 | p = 0.239 |
| Continuous 1 log2 (IL-18)B | 65 | 68 | 1.42 (0.82, 2.47) | 1.73 (0.88, 3.42) | 1.74 (0.88, 3.47) |
Model 1 = age, gender and region.
Model 2 = model 1 + SEP + smoking + alcohol + physical activity + history of diabetes + BMI + SBP + DBP + TC + HDL.
Model 3 = model 2 + logIL-6 + logCRP.
A
Complete case analysis sample. Tertiles based on control group. P value for test for trend over tertiles.
B
OR of MI per 1 log2 increase in log2(IL-18) i.e. doubling of IL-18.