Table 2.

Summary of the model’s inputs and outputs

	Clinical	Cost	Parameters
Model inputs	FEV1 boost/improvement Exacerbations Mortality TDI SGRQ Withdrawals HR-QOL	Drugs Exacerbations Maintenance	Time horizon Cycle length Discount rate Number of patients Number of cohorts to be run
Model outputs	Number of days in each disease severity Number of exacerbations (non-severe and severe) Average SGRQ score in each arm Mean difference of FEV1 Annual FEV1 decline rate QALYs	Total and average drug costs Exacerbations Maintenance costs	NA
Cost-effectiveness outputs	ICER ICUR Cost-effectiveness plane		NA

FEV ₁ forced expiratory volume in 1 second, HR-QOL health-related quality of life, ICER incremental cost-effectiveness ratio, ICUR incremental cost-utility ratio, NA not applicable, SGRQ St. George’s Respiratory Questionnaire, TDI Transition Dyspnoea Index