Table 2. Liver UPR Transcripts Significantly Altered in Both T/HS vs. Sham and T/HS/IL6 vs. T/HS Comparisons.
| Regulation | Fold Change | |||||
|---|---|---|---|---|---|---|
| Gene Symbol | UPR Function | Apoptosis Function | T/HSvs Sham | T/HS-IL6 vs T/HS | T/HS vs Sham | T/HS-IL6 vs T/HS |
| Hspa1a/Hspa1b (Hsp70) | Chaperone | Anti | up | up | 25.6 | 5.5 |
| Hspa1b (Hsp70-1b) | Chaperone | Anti | up | up | 18.4 | 5.9 |
| Ero1I | Disulfide Bond Formation | Anti | up | down | 9.8 | −3.8 |
| Dnajb1 (Hsp40 Subunit b1) | Chaperone | Anti | up | up | 5.9 | 2.7 |
| Atf4 | Transcription Factor | Anti/Pro | up | down | 3.1 | −2.0 |
| Casp3 (caspase 3) | Apoptosis Signalling | Pro | up | down | 1.8 | −1.7 |
| Eif2s1 (Eif2α) | Protein Transtation | Anti | up | down | 1.7 | −1.6 |
| Sels | Modulation of ATF6 | Uknown | up | down | 1.5 | −1.3 |
| Eif2ak3 (PERK) | UPR Sensory Molecule | Anti/Pro | up | down | 1.4 | −1.3 |
| Psmb3 | Proteasome Degradation | Anti | down | up | −1.2 | 1.3 |
| Calr (calreticulin) | Chaperone | Anti | down | up | −1.2 | 1.2 |
| Uba1 | Ubiquitination | Anti | down | up | −1.3 | 1.2 |
| Psme2 | Proteasome Degradation | Anti | down | up | −1.3 | 1.4 |
| Psme1 | Proteasome Degradation | Anti | down | up | −1.3 | 1.2 |
| Dyt1 | ATPase | Anti | down | up | −1.4 | 1.4 |
| Tmbim6 (Baxinhibitor 1) | Apoptosis Signalling | Anti | down | up | −1.5 | 1.3 |
| Ccnd1 | Cell Cycle Signalling | Anti | down | up | −3.4 | 2.3 |