Table 4. Heart UPR Transcripts Significantly Altered in Both T/HS vs. Sham and T/HS/IL6 vs. T/HS Comparisons.
| Regulation | Fold Change | |||||
|---|---|---|---|---|---|---|
| Gene Symbol | UPR Function | Apoptosis Function | T/HS vs Sham | IL6 vs T/HS | T/HSvs Sham | IL6 vs T/HS |
| Hspa1a/Hspa1b (Hsp 70) | Chaperone | Anti | up | down | 10 | −6.4 |
| Hspa1b (Hsp701b) | Chaperone | Anti | up | down | 7.5 | −4.9 |
| Cebpb | Transcription factor | Pro | up | down | 5.1 | −1.7 |
| Dnaja1 (Hsp40 subunit) | Co-chaperone | Anti | up | down | 3.1 | −2.3 |
| Hsph1 (Hsp 105) | Chaperone | Anti | up | down | 2.5 | −2.1 |
| Dnajb1 (Hsp40 subunit) | Co-chaperone | Anti | up | down | 2.2 | −2 |
| Nfe2l2 | Transcription factor | Anti | up | down | 2 | −1.4 |
| Ppp1r15a (GADD34) | Transcription factor | Pro | up | down | 2 | −1.4 |
| Xbp1 (X-box-protein 1) | Transcription factor | Pro | up | down | 1.5 | −1.2 |
| Tra1 (Hsp90b1) | Chaperone (ERAD) | Anti | up | down | 1.4 | −1.3 |
| Calr (calreticulin) | Chaperone | Anti | up | down | 1.4 | −1.3 |
| Ddit3 (CHOP) | Transcription factor | Pro | up | down | 1.4 | −1.3 |
| Serp1 | protects unfolded proteins from ERAD | Anti | up | down | 1.3 | −1.2 |
| Sp1 | Transcription factor | Pro | down | up | −1.2 | 1.3 |
| Sels | modulates ATF6 | Unknown | down | up | −1.5 | 1.3 |
| Pik3ip1 | negative regulator of PERK | Anti | down | up | −3 | 1.4 |
Abbreviation: ERAD, endoplasmic reticulum-associated degradation.