Skip to main content
. 2013 Feb 1;3:1196. doi: 10.1038/srep01196

Figure 5. Titers of plasma anti-drug antibodies after 4-week treatment with 0.1, 0.25 and 0.5 mg/body of TCZ in each genotype of mouse (n = 5 per group).

Figure 5

Extremely high levels of plasma anti-TCZ-antibody titers were detected in Il6ra+/+-hIL6 transgenic mice, whereas those in TCZ-treated Il6rahIL6R/hIL6R-hIL6 transgenic mice were minimally detected. Non Tg, hIL6 non-transgenic mice; Tg, hIL6 transgenic mice.