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. 2013 Feb 1;4:15. doi: 10.3389/fimmu.2013.00015

FIGURE 1.

FIGURE 1

A novel strategy for HSC transplantation from haploidentical donors. In this protocol, HSC-enriched cell populations are obtained by negative selection upon removal of TCR α/β+ T cells and CD19+ B cells. Notably, in addition to CD34+ cells, these cell suspensions contain mature NK cells and TCR γ/δ+ T cells. Using this strategy, two sources of alloreactive NK cells will come into play: (1) those generated from CD34+ cells after 6–8 weeks from transplantation and (2) those present in the fresh cell suspension infused into patients. It is evident that the prompt availability of alloreactive effector cells may greatly improve the anti-leukemia effect and the removal of residual patient’s DCs and T lymphocytes, thus ensuring a more efficient prevention of leukemic relapses, GvHD and graft-rejection. In addition, transplanted NK and γ/δ T cells may provide a first line of defense against different infectious agents.