Table 1.
KIRs and KIR-ligands.
| KIR | Domain composition | KIR-ligand | Function | Reference |
|---|---|---|---|---|
| 2DL1 | D1 + D2 | HLA-CLys80 (C2) | Inhibitory | Ciccone et al. (1992a), Biassoni et al. (1995) |
| 2DL2/2DL3 | D1 + D2 | HLA-CAsn80 (C1), HLA-B*46:01, HLA-B*73:01 Low affinity: HLA-CLys80 (C2) |
Inhibitory | Ciccone et al. (1992a), Biassoni et al. (1995), Moesta et al. (2008) |
| 2DL4 | D0 + D2 | HLA-G | Inhibitory and activating* | Rajagopalan et al. (2001) |
| 2DL5 | D0 + D2 | Unknown | Inhibitory | |
| 3DL1 | D0 + D1 + D2 | HLA-BBw4 and some HLA-ABw4 | Inhibitory | Gumperz et al. (1997), Stern et al. (2008) |
| 3DL2 | D0 + D1 + D2 | HLA-A*03 and HLA-A*11 | Inhibitory | Döhring et al. (1996), Pende et al. (1996) |
| 2DS1 | D1 + D2 | HLA-CLys80 (C2) | Activating | Stewart et al. (2005), Chewning et al. (2007) |
| 2DS2 | D1 + D2 | Unknown | Activating | |
| 2DS3 | D1 + D2 | Unknown | Activating | |
| 2DS4 | D1 + D2 | HLA-A*11 and some HLA-C alleles | Activating | Graef et al. (2009) |
| 2DS5 | D1 + D2 | Unknown | Activating | |
| 3DS1 | D0 + D1 + D2 | HLA-BBw4 (?) | Activating | Martin et al. (2002) |
*
KIR2DL4 may function as an inhibitory receptor in cytotoxicity while it triggers IFN-γ production.