Table 4.

Change from baseline in 6MWD, NT-proBNP, and WHO functional class

	Week 6	Week 12	Month 6	Month 12
6MWD, ma	9.5 (−14 to 35)d	16.0 (−8 to 39)e	26.0 (−3 to 51)e	27.0 (−7 to 54)d
BDIa	−0.54 (0.20)c	−0.66 (0.22)d	−0.51 (0.27)ns	−1.06 (0.36)d
NT-proBNP, pg/mLb	−80 (−376 to 50)e	−74 (−339 to 37)d		−111 (−345 to 93)ns
WHO functional class
Improved	4 (6)	6 (9)	11 (19)	7 (29)
Maintained	61 (87)	60 (87)	45 (78)	16 (67)
Worsened	5 (7)	3 (4)	2 (3)	1 (4)

Values presented as median (interquartile range), mean (SE), or n (%). 6MWD, 6-min walk distance; BDI, borg dyspnea index; NT-proBNP, N-terminal pro-B-type natriuretic peptide.

^a6MWD and BDI data for n = 70 (week 6), n = 68 (week 12), n = 55 (month 6), and n = 23 (month 12).

^bNT-proBNP data for n = 69 (week 6), n = 68 (week 12), and n = 24 (month 12).

^cP < 0.05.

^dP < 0.01.

^eP < 0.001.

ns, not significant.